Journal of Clinical and Experimental Ophthalmology
Open Access

Jean-Olivier Durand

Publications

• Research Article
  Functionalized Nanoparticles for Drug Delivery, One- and Two-photon Photodynamic Therapy as a Promising Treatment of Retinoblastoma
  Author(s): Audrey Gallud, Afitz Da Silva, Marie Maynadier, Ilaria Basile, Simon Fontanel, Cyndie Lemaire, Philippe Maillard, Mireille Blanchard-Desce, Olivier Mongin, Alain Morere, Jean-Olivier Durand, Laurence Raehm, Marcel Garcia and Magali Gary-BoboAudrey Gallud, Afitz Da Silva, Marie Maynadier, Ilaria Basile, Simon Fontanel, Cyndie Lemaire, Philippe Maillard, Mireille Blanchard-Desce, Olivier Mongin, Alain Morere, Jean-Olivier Durand, Laurence Raehm, Marcel Garcia and Magali Gary-Bobo
  
  Retinoblastoma is a rare cancer triggered by genetic mutation that forms in the eyes of children. In industrialized countries, 95% of patients are cured by chemotherapy and conservative treatments. However these treatments can increase the risk of secondary tumors in patients with a constitutional alteration of the retinoblastoma gene Rb1. Photodynamic therapy (PDT) represents a therapeutic approach and may reduce the incidence of secondary tumors. PDT is an established cancer treatment based on the light activation of a photosensitizing agent thus generating cytotoxic reactive oxygen species that cause cellular damage. We focused on mesoporous silica nanoparticles (MSN) for one-photon excited PDT combined with drug delivery and carbohydrate targeting applied on retinoblastoma. We demonstrated that bitherapy (camptothecin delivery and PDT) performed with MSN was efficient in inducing .. View More»
  DOI: 10.4172/2155-9570.1000288

  Abstract PDF

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