Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Jemma Thornes
United Kingdom
Research Article
Autoantibodies against C1q as a Diagnostic Measure of Lupus Nephritis: Systematic Review and Meta-analysis
Author(s): Paul Eggleton, Obioha C. Ukoumunne, Isabel Cottrell, Asma Khan, Sidra Maqsood, Jemma Thornes, Elizabeth Perry and David IsenbergPaul Eggleton, Obioha C. Ukoumunne, Isabel Cottrell, Asma Khan, Sidra Maqsood, Jemma Thornes, Elizabeth Perry and David Isenberg
Objectives: To evaluate the diagnostic accuracy of C1q autoantibodies in identifying lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE).Data sources and methods: Citation indexes were searched and 370 articles published from 1977 to 2013 were evaluated. The 31 selected studies included in the meta-analysis were cross-sectional in design. Among the 31 studies, 28 compared anti-C1q antibodies in 2769 SLE patients including those with (n=1442) and without a history of LN (n=1327). Nine studies examined anti-C1q in 517 SLE patients with active (n=249) and inactive LN (n=268). Hierarchical summary receiver operating characteristic (HSROC) random effects models were fitted to pool estimates of accuracy across the studies.Results: Anti-C1q antibodies discriminated between patients with and without a history .. View More»
DOI:
10.4172/2155-9899.1000210