Journal of Infectious Diseases & Preventive Medicine
Open Access

Jennifer R DiBiagio

Publications

• Commentary
  Alzheimer’s disease: A Commentary on Biofilms, Beta Amyloid and their Locations
  Author(s): Jennifer R DiBiagio, Suresh G Joshi and Herbert B Allen Jennifer R DiBiagio, Suresh G Joshi and Herbert B Allen
  
  The pathological study of brains affected by Alzheimer’s disease (AD) has shown the presence of spirochetal infection. These bacteria produce a detectible biofilm as a defense mechanism, impenetrable by both the immune system and antibiotic medications. The failure of the innate immune system at the site of biofilm deposition ultimately leads to the pathognomonic beta-amyloid (Aβ) plaques of AD at the exact same location as visualized by immunological staining. Furthermore, recent studies show that senile plaques are partially composed of bacterial Aβ in addition to that of the host. The bacterial and neuropathology similarities continue with similar staining results using all of the following: silver impregnation techniques, green thioflavin S fluorescence, anti-AβPP, and anti-AβPP antibodies. TUNEL assay of senile plaques further support the DAPI visualizat.. View More»
  DOI: 10.4172/2329-8731.1000140

  Abstract PDF

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