Journal of Leukemia
Open Access

Jeong Nyeo Lee

Publications

• Case Report
  Acute Myeloid Leukemia with t(2;6)(q12;q12) Reveals Dysmegakaryopoietic Finding and Poor Prognosis
  Author(s): Jong Ae Son, Kyung Ran Jun, Eul-Ju Seo, Young-don Joo, Seung Hwan Oh, Ja Young Lee, Jeong Hwan Shin, Hye Ran Kim and Jeong Nyeo Lee Jong Ae Son, Kyung Ran Jun, Eul-Ju Seo, Young-don Joo, Seung Hwan Oh, Ja Young Lee, Jeong Hwan Shin, Hye Ran Kim and Jeong Nyeo Lee
  
  We present a case of acute myeloid leukemia (AML) with a balanced translocation between chromosomes 2q12 and 6q12, t(2;6)(q12;q12). This abnormality was defined by conventional cytogenetics and multicolor banding techniques using specific probes for chromosome 2. Blasts accounted for 2% of white blood cells in peripheral blood and approximately 30% of all nucleated cells in marrow aspirates. They were medium-to-large cells with fine nuclear chromatin, indistinct nucleoli and basophilic cytoplasm. Immunophenotyping indicated the blasts were of myeloid lineage with aberrant CD7 expression. Therefore, the patient was diagnosed as ?Acute myeloid leukemia, NOS, AML with maturation? according to the WHO classifications. In literature review, this case should be considered as the first report of AML with t(2;6)(q12;q12). Interestingly, a bone marrow smear showed dysmegakaryopoietic findings, su.. View More»
  DOI: 10.4172/2329-6917.1000116

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