Biochemistry & Pharmacology: Open Access
Open Access

Jeremiah Goodness Chiamaka

Publications

• Research Article
  Ameliorative Effect of the Flavonoid Rich Fraction of Monodora myristica (Gaertn) Dunel Seed Extract against Carbon Tetrachloride-Induced Hepatotoxicity and Oxidative Stress in Rats
  Author(s): Ekeanyanwu Raphael Chukwuma and Jeremiah Goodness Chiamaka Ekeanyanwu Raphael Chukwuma and Jeremiah Goodness Chiamaka
  
  The study investigated the protective effect of the flavonoid rich fraction (FRF) of M. myristica on carbon tetrachloride induced hepatotoxicity and oxidative stress in experimental animals. Wistar albino rats of both sexes were maintained on 1.0 ml/kg b.wt of carbon tetrachloride to induce hepatotoxicity and oxidative stress. Added to this, the animals received FRF at a dose of 250 or 500 and 100 mg/kg b.wt of silymarin for 8 days. At the end of the experiment, levels of serum hepatic enzyme biomarkers (SGOT, SGPT and SALP) as well as lipid peroxidation product (MDA) and total bilirubin were significantly raised in the CCl4 treated groups. Conversely, CCl4 administration elicited obvious decline in enzymatic antioxidants activities and non-enzymatic antioxidants (GSH, CAT, SOD, vitamin C, vitamin E) co-administration with FRF of M. myristica at varying doses as well.. View More»
  DOI: 10.4172/2167-0501.1000232

  Abstract PDF

Relevant Topics