Journal of Clinical and Experimental Ophthalmology
Open Access

Jerry Y Niederkorn

Publications

• Review Article
  Immunology of Corneal Allografts: Insights from Animal Models
  Author(s): Jerry Y NiederkornJerry Y Niederkorn
  
  Corneal transplantation stands alone as the most common and successful form of solid organ transplantation. Even though HLA matching and systemic antirejection drugs are not routinely used, 90% of the first time corneal allografts will succeed. By contrast, all other major categories of organ transplantation require HLA matching and the use of systemically administered immunosuppressive drugs. This remarkable success of corneal transplants under these conditions is an example of “immune privilege” and is the primary reason for the extraordinary success of corneal transplantation. A number of dogmas have emerged over the past century to explain immune privilege and the immunobiology of corneal transplantation. Many of these dogmas have been based largely on inferences from clinical observations on keratoplasty patients. The past 30 years have witnessed a wealth of rodent st.. View More»
  DOI: 10.4172/2155-9570.1000429

  Abstract PDF

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