Journal of Depression and Anxiety
Open Access
ISSN: 2167-1044
+44 1223 790975
ISSN: 2167-1044
+44 1223 790975
Jia Chen
Icahn School of Medicine at Mount Sinai,
One Gustave L. Levy Place, New York, NY, 10029
Tanzania
Research Article
Influences of Maternal Stress during Pregnancy on the Epi/genome: Comparison of Placenta and Umbilical Cord Blood
Author(s): Jia Chen, Qian Li, Alexender Rialdi, Elana Mystal, Jenny Ly, Jackie Finik, Taira Davey, Luca Lambertini and Yoko Nomura
Jia Chen, Qian Li, Alexender Rialdi, Elana Mystal, Jenny Ly, Jackie Finik, Taira Davey, Luca Lambertini and Yoko Nomura
Background: Maternal stress during pregnancy is one of the major adverse environmental factors in utero that is capable of influencing health outcomes of the offspring throughout life. Both genetic and epigenetic processes are susceptible to environmental insults in utero and are potential biomarkers of the experienced environment including maternal stress.
Methods: We profiled expression level of six genes in hypothalamic pituitary adrenal (HPA) axis functioning (HSD11B2, SLC6A4, NR3C1, NR3C2, CRHR1 and CRHR2), two imprinted genes (IGF2 and H19) and one neurodevelopmental gene (EGR1), from 49 pairs of placenta and umbilical cord blood (UCB) samples from a birth cohort. We also assessed global methylation levels by LUminometric Methylation Assay (LUMA) and methylation at the imprinting control region (ICR) of IGF2/H19.
Resu.. View More»
DOI:
10.4172/2167-1044.1000152