Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Jian-an Huang
Suzhou 215123
Indiana
Research Article
MicroRNA-205 Promotes Cell Proliferation of Non-Small Cell Lung Cancer by Targeting Smad4
Author(s): Yuanyuan Zeng, Jianjie Zhu, Xiaoxue Song, Sonia F Erfani, Hualong Qin, Zhe Lei, Dan Shen, Xiuwei H Yang, Zeyi Liu and Jian-an HuangYuanyuan Zeng, Jianjie Zhu, Xiaoxue Song, Sonia F Erfani, Hualong Qin, Zhe Lei, Dan Shen, Xiuwei H Yang, Zeyi Liu and Jian-an Huang
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and the leading cause of cancerrelated death worldwide. Despite recent advances in cancer diagnosis and treatment, the survival rate of NSCLC patients remains dismally low. There is an urgent need for better mechanistic understanding and development of novel diagnostic and treatment strategies against this malignant disease. MicroRNAs (miRNAs), a class of 19- to 24- base pair non-coding RNAs, have increasingly been implicated as crucial regulators of NSCLC malignancy, and promising biomarkers and/or therapeutic targets for such aggressive disease. Here, we report clinical, molecular, and functional studies of miR-205 in NSCLC. Our analyses of an NSCLC patient cohort showed that expression of miR-205 in primary tumors was 7-fold higher than their corresponding adjacent noncancerous ti.. View More»
DOI:
10.4172/2155-9899.1000328