Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-77-2385-9429
ISSN: 2167-0501
+44-77-2385-9429
Jie Wu
Tanzania
Review Article
Modulation of the Endogenous Cannabinoid System as a Therapeutic Target in the Treatment of Mental Health Disorders
Author(s): Harrison J Stratton, Darien L Allen, Jie Wu and Michael S ShaferHarrison J Stratton, Darien L Allen, Jie Wu and Michael S Shafer
Focus on developing more effective therapeutic interventions to assuage the symptoms of mental health disorders has been a significant driving force in our search to understand the human brain. Current treatments for mental health disorders rely on modulating neurotransmitter systems such as norepinephrine, serotonin, dopamine, and GABA to achieve therapeutic relief of symptoms. While there are many medications that individually target these specific systems, treatment often leads to unwanted side effects or incomplete relief. To counter this lack of treatment efficacy, we must investigate other avenues of achieving the same or better outcomes to potentially reach those patients resistant to common treatments. One of these systems is the Endogenous Cannabinoid System (ECS), which is composed of the metabotropic CB1 and CB2 receptors. These G protein coupled receptors are responsible f.. View More»
DOI:
10.4172/2167-0501.S1-008