Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Jing Wang
China
Review Article
Natural Killer cells in Innate Defense against Infective Pathogens
Author(s): Dongfang Wang, Yongchao Ma, Jing Wang, Xiaoman Liu, Min FangDongfang Wang, Yongchao Ma, Jing Wang, Xiaoman Liu, Min Fang
Infectious diseases cause over 300 million illnesses and more than 5 million deaths each year worldwide. Understanding how components of the host immune system function to control disease-causing pathogens is critically important to develop strategies for preventing and controlling these diseases. With the discovery of innate immune receptors, we are beginning to appreciate the important role of innate immunity in the defense against infectious diseases. NK cells are a critical cell population in innate immunity, providing first line of defense against a variety of pathogens. NK cells mediate protection by direct killing of infected target cells and producing cytokines (mainly IFN-γ and TNF) that shape innate and adaptive immune responses. Recent studies have focused on the mechanisms by which NK cells recognize and respond to viruses, bacteria and parasites, and also the role of.. View More»
DOI:
10.4172/2155-9899.S13-006