Rheumatology: Current Research
Open Access

Jing Wang

Publications

• Research Article
  Rs4676410 and Rs2531875 are Associated with the Risk of Ankylosing Spondylitis in the Han Chinese Population
  Author(s): Qingwen Wang, Ping Li, Jing Wang, Qi Lin, Luo Wang and Zhengyu Fang Qingwen Wang, Ping Li, Jing Wang, Qi Lin, Luo Wang and Zhengyu Fang
  
  Objectives: Although the exact cause of ankylosing spondylitis (AS) is unknown, genetics play a key role in AS. A recent genome-wide association study identified new immune-related susceptibility loci for AS in East Asians, and these need to be validated in the Chinese population. Methods: We enrolled 848 patients who met the modified New York criteria for AS and 1123 healthy normal controls in the present study. High-resolution melting analysis accompanied with sequencing was carried out to genotype five polymorphisms: rs12615545, rs4676410, rs1250550, rs2531875, and rs7282490. Distributions of genotypes and alleles were compared between AS patients and healthy controls, and among AS patients stratified by clinical parameters, age, and gender. Results: rs4676410 (p=0.0237; odds ratio (OR): 1.109; 95% confidence in.. View More»
  DOI: 10.4172/2161-1149.S5-007

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