Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Jing Wen Zhang
Indiana
Research Article
Effect of Angiopoietin-Like Protein 4 on Severe Acute Pancreatitis-induced Lung Injury in Rats
Author(s): Yu Xi Wang, Hai Long Chen, Shang Shao Sun, Hai Long Li, Jing Wen Zhang, Xiao Yu Sun and Liang CaoYu Xi Wang, Hai Long Chen, Shang Shao Sun, Hai Long Li, Jing Wen Zhang, Xiao Yu Sun and Liang Cao
Numbers of therapeutic options have been explored for acute pancreatitis (AP), but none has been proven to be effective in clinic. Angiopoietin-like 4 (Angptl4) is a circulating protein, predominantly expressed in the liver and adipose tissue. Overexpression of Angptl4 has been explored in regulating lipid metabolism and angiogenesis. However, Angptl4 is the target gene of preoxisome proliferation activators-PPARs, the latter has been studied with its anti-inflammatory effects. In this study, we investigated effects of Angptl4 on severe acute pancreatitis-induced lung injury in rats. Acute Pancreatitis was induced by retrograde infusion of 1.5% deoxycholic acid sodium salt (1 mg/kg) into the bile-pancreatic duct. The severity of pancreatitis was verified by serum amylase (AMY) and alanine aminotransferase (ALT) levels. BCL-2 expression was observed in pancreatitis tissue perf.. View More»
DOI:
10.4172/2155-9899.1000135