Journal of Clinical and Experimental Ophthalmology
Open Access

Joan M O’Brien

Publications

• Research Article
  Mitochondrial Haplogroup L1c2 Is Associated With Increased Disease Severity in African American Patients with Primary Open-Angle Glaucoma
  Author(s): Qi N Cui, Meera S Ramakrishnan, Harini V Gudiseva, David W Collins, Maxwell Pistilli, Roy Lee, Venkata M Chavali, Amanda Lehman, Victoria M Addis and Joan M O’BrienQi N Cui, Meera S Ramakrishnan, Harini V Gudiseva, David W Collins, Maxwell Pistilli, Roy Lee, Venkata M Chavali, Amanda Lehman, Victoria M Addis and Joan M O’Brien
  
  Objective: The purpose of this study is to evaluate the role mitochondrial inheritance plays in primary open-angle glaucoma (POAG) characteristics in African Americans. Methods: POAG cases from the L1c2 and L1b mitochondrial haplogroups were compared in a retrospective case-case study. Twenty-six pairs of self-identified African American POAG cases from L1c2 and L1b mitochondrial haplogroups matched on age (mean [SD]=71.2 [9.6] and 71.3 [9.6] years, respectively; p=0.97), sex (21 female and 5 male pairs), and family history of glaucoma (positive in 15/26 [58%] pairs) were included. Results and Discussion: L1c2 subjects displayed higher vertical cup-to-disc ratio (0.75 [0.12] and 0.67 [0.16], respectively; p=0.01, Bonferroni-corrected p=0.08), worse pattern standard deviation on visual field (VF) testing (5.5 [3.5] and .. View More»
  

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