Gynecology & Obstetrics
Open Access

Joergensen J

Publications

• Research Article
  Relaxant Effect of Cyppa In Vitro and Expression Analysis of SK3 Splice Variants in the Myometrium of Pregnant and Non-Pregnant Women
  Author(s): Rosenbaum ST, Svalo J, Larsen T, Joergensen J and Bouchelouche PRosenbaum ST, Svalo J, Larsen T, Joergensen J and Bouchelouche P
  
  Background and objective: We have recently shown an overall down-regulation of SK3 channels in pregnant human myometrium compared to non-pregnant myometrium. The aim of this study was to investigate whether SK3 splice variants are involved in the down-regulation of SK3 channels. We also tested whether SK channels are implicated in myometrial contractility using CyPPA, a novel and selective SK2 and SK3 channel activator. Study design: We evaluated the expression of SK3 splice variants at mRNA level by qRT-PCR in myometrium from pregnant (n=11) and non-pregnant (n=11) women. Isometric tension recordings were performed to assess human myometrial contractility on biopsies obtained at elective caesarean section at term (n=6) and from hysterectomy (n=6). We investigated the effects of CyPPA (0.1-60 μM) on spontaneous contractions. .. View More»
  DOI: 10.4172/2161-0932.1000171

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