Lupus: Open Access
Open Access

John D Wetherall

Publications

• Research Article
  Anti-C1Q Antibodies Concentrations by Elisa in Systemic Lupus Erythematosus
  Author(s): Audrey A Margery-Muir, John D Wetherall, David M Groth and Christine BundellAudrey A Margery-Muir, John D Wetherall, David M Groth and Christine Bundell
  
  Systemic lupus erythematosus (SLE) is an inflammatory disorder in which autoantibodies contribute to impaired apoptosis and clearance of cell debris. Anti dsDNA and anti C1q antibodies have been implicated, as well as complement protein C1q itself. IgG autoantibodies reacting with the collagen-like region of C1q protein (αC1q ab) were quantitated in serum of 56 patients diagnosed with SLE and undergoing treatment for variable periods, together with 33 age/sex-matched controls. Analysis of the results showed optimal sensitivity and specificity of 57% and 91% respectively at a cut-off concentration for positivity of 20 U/ml. The assay is a potentially useful confirmatory test for SLE, but is not suitable as a screening test for SLE with the probability of a positive test and SLE in an individual within a random population of only ≤ 1%. αC1q ab concentrations were detectab.. View More»
  DOI: 10.35248/2684-1630.17.2.124

  Abstract PDF

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