Journal of Thyroid Disorders & Therapy
Open Access

John I Lew

Publications

• Research Article
  Family History Correlates with More Aggressive Variants of Papillary Thyroid Cancer
  Author(s):  John I Lew  John I Lew
  
  Background: Papillary thyroid cancer (PTC) generally occurs sporadically but about 5% of cases are familial in origin. Furthermore, family history has been established as an influential risk factor for PTC. This study determines whether patients with a family history of thyroid cancer harbor more aggressive variants of PTC. Materials and Methods: A retrospective review of prospectively collected data of 1779 consecutive patients who underwent thyroidectomy was performed. Patients were divided into patients who had a history of PTC in first degree relatives (n=39) and those that did not (n=1740). Patients with PTC on final pathology were further subdivided into those with less aggressive (classic and follicular) and patients with more aggressive (diffuse sclerosing and tall cell) variants of PTC. A two tailed Z test at a significance level of p&.. View More»
  DOI: 10.4172/2167-7948.1000175

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