Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
John M. Nolan
Ireland
Research Article
Visual Function and Its Relationship with Severity of Early, and Activity of Neovascular, Age-Related Macular Degeneration
Author(s): James Loughman, Sarah Sabour-Pickett, John M. Nolan, Barbara Klein, Ronald Klein, Stephen BeattyJames Loughman, Sarah Sabour-Pickett, John M. Nolan, Barbara Klein, Ronald Klein, Stephen Beatty
Purpose: To investigate the relationship between visual function and severity of early age-related macular degeneration (AMD) and activity of neovascular (nv-) AMD. Methods: The following data was collected from 66 eyes of 66 subjects with early AMD and 47 eyes of 47 subjects with active nv-AMD: corrected distance visual acuity (CDVA); contrast sensitivity (CS); glare disability (GD); and retinotopic ocular sensitivity (ROS) of the central 5° of the retina, by microperimetry. Fundus photographic grading of early AMD was performed in a masked fashion. Mean foveal thickness (MFT) was measured by spectral domain optical coherence tomography in patients with nv-AMD. Results: In subjects with early AMD, there was an inverse and statistically significant relationship between measures of ROS within the central 5° of retina (including fixation) and severity of early AMD (p=0.01). In.. View More»
DOI:
10.4172/2155-9570.1000488