Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
John Matthew Bryant
Tanzania
Review Article
Fc Receptor-Like Proteins in Pathophysiology of B-cell Disorder
Author(s): Mollie Capone, John Matthew Bryant, Natalie Sutkowski and Azizul Haque
Mollie Capone, John Matthew Bryant, Natalie Sutkowski and Azizul Haque
Members of the family of Fc receptor-like (FcRL) proteins, homologous to FcγRI, have been identified by multiple research groups. Consequently, they have been described using multiple nomenclatures including Fc receptor homologs (FcRH), immunoglobulin superfamily receptor translocation-associated genes (IRTA), immunoglobulin-Fcgp42- related genes (IFGP), Src homology 2 domain-containing phosphatase anchor proteins (SPAP), and B cell cross-linked by anti-immunoglobulin M-activating sequences (BXMAS). They are now referred to under a unified nomenclature as FCRL. Eight different human FCRL genes have been identified, all of which appear to be related to the genes of the immunoglobulin superfamily (IgSF) of cellular adhesion molecules. These type 1 transmembrane glycoproteins are composed of different combinations of 5 types of immunoglobulin-like domains, with each protein consist.. View More»
DOI:
10.4172/2155-9899.1000427