Journal of Clinical and Cellular Immunology
Open Access

John Pedersen

Publications

• Research Article
  Therapeutic Targeting of the Cancer-Specific Cell Surface Biomarker nfP2X₇
  Author(s): Julian A Barden, Angus Gidley-Baird, Liew Cheng Teh, G-Halli Rajasekariah, John Pedersen, Neil I Christensen, Derek Spielman and David M Ashley Julian A Barden, Angus Gidley-Baird, Liew Cheng Teh, G-Halli Rajasekariah, John Pedersen, Neil I Christensen, Derek Spielman and David M Ashley
  
  The degree of unmet need for new therapeutics in oncology is clear since about 30% of the population die from cancer with enormous associated costs in health care and in personal impact. New and preferably specific targets are needed now to address the problem, both to improve overall survival and importantly to reduce side effects in order to improve quality of life. nfP2X7 is a receptor that, unlike P2X7, cannot enable apoptosis in cancer cells. Having established the widespread coverage of human cancers in which the aberrant receptor is found, attention has been drawn to the therapeutic potential of the target and whether an immunotherapeutic approach is capable of providing a significant therapeutic response. We demonstrate the intrinsic target specificity, the delivery of antibody within target cells, the extremely good safety profile of the targeting antibody and the broad range.. View More»
  DOI: 10.4172/2155-9899.1000432

  Abstract PDF

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