Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
John W Chen
Massachusetts General Hospital and Harvard Medical School,
185 Cambridge Street, Boston, MA 02114
Tanzania
Review Article
Imaging Neuroinflammation – from Bench to Bedside
Author(s): Benjamin Pulli and John W ChenBenjamin Pulli and John W Chen
Neuroinflammation plays a central role in a variety of neurological diseases, including stroke, multiple sclerosis, Alzheimer’s disease, and malignant CNS neoplasms, among many other. Different cell types and molecular mediators participate in a cascade of events in the brain that is ultimately aimed at control, regeneration and repair, but leads to damage of brain tissue under pathological conditions. Non-invasive molecular imaging of key players in the inflammation cascade holds promise for identification and quantification of the disease process before it is too late for effective therapeutic intervention. In this review, we focus on molecular imaging techniques that target inflammatory cells and molecules that are of interest in neuroinflammation, especially those with high translational potential. Over the past decade, a plethora of molecular imaging agents have been develo.. View More»
DOI:
10.4172/2155-9899.1000226