Biochemistry & Pharmacology: Open Access
Open Access

Johnson KR

Publications

• Review Article
  Compensating for Cardiac Hypertrophy: A Crucial Role for A-Kinase Anchoring Protein-Lbc
  Author(s): Johnson KR, Wang L and Carnegie GK Johnson KR, Wang L and Carnegie GK
  
  In response to mechanical load, cardiac hypertrophy (myocyte enlargement) is initially compensatory, but becomes a maladaptive process that leads to the development of heart failure. The high prevalence of pathological myocardial hypertrophy in cardiovascular disease coupled with a lack of effective treatment highlights a need for novel therapeutic strategies in this area. Recently, a diverse family of scaffold proteins termed A-Kinase Anchoring Proteins have been identified and characterized, playing multiple important roles in the heart. In a recent study using a mouse model with a partial AKAPLbc (AKAP13) gene deletion, we demonstrate a crucial in vivo role for AKAP-Lbc-protein kinase D1 (PKD1) signaling in the development of compensatory hypertrophy in response to transverse aortic constriction (TAC)-induced pressure overload and neurohumoral stimulation by AT-II/PE.. View More»
  DOI: 10.4172/2167-0501.1000147

  Abstract PDF

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