Journal of Clinical & Experimental Dermatology Research
Open Access

Jonathan H Zippin

Publications

• Review Article
  Cyclic Adenosine Monophosphate Signaling in Inflammatory Skin Disease
  Author(s): Jack Levy, Dalee M Zhou and Jonathan H Zippin Jack Levy, Dalee M Zhou and Jonathan H Zippin
  
  The second messenger cyclic adenosine monophosphate (cAMP) regulates numerous key pathways that impact the immune system. Distinct cellular cAMP signaling pathways can lead to both pro- and anti-inflammatory effects depending upon the cell type. When dysregulated, these cAMP pathways can influence the pathogenesis of inflammatory cutaneous diseases, such as atopic dermatitis and psoriasis. In psoriasis and atopic dermatitis, cAMP and/or its effector proteins (e.g., protein kinase A) are downregulated suggesting that elevation of cAMP might be a therapeutic option. cAMP levels are the result of balance between synthesis by adenylyl cyclases and degradation by phosphodiesterases (PDEs). Pharmacologically inhibiting PDEs represents one effective mechanism to raise intracellular cAMP levels perhaps leading to targeted immune suppression. Several drugs have been developed to target PDEs an.. View More»
  DOI: 10.4172/2155-9554.1000326

  Abstract PDF

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