Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

José Artur Bogo Chies

Publications

• Research Article
  Polymorphisms of the Apoptotic genes TP53 and MDM2 and Preeclampsia Development
  Author(s): Mauricio Busatto, Lucas Rosa Fraga, Juliano Andr? Boquett, Diego Luiz Rovaris, Fernanda Sales Luiz Vianna, Lav?nia Schuler Faccini, Jos? Artur Bogo Chies and Priscila Vianna Mauricio Busatto, Lucas Rosa Fraga, Juliano Andr? Boquett, Diego Luiz Rovaris, Fernanda Sales Luiz Vianna, Lav?nia Schuler Faccini, Jos? Artur Bogo Chies and Priscila Vianna
  
  Preeclampsia (PE) is a multisystemic disorder responsible by high levels of maternal/fetal mortality and morbidity. Although its exact physiology is not well established, apoptosis has a pivotal role in PE pathophysiology, and an elevated rate of cell death is related to PE development. Here it was performed a case-control study, where the frequencies of two polymorphisms in major genes of the apoptosis pathway (TP53 rs1042522 and MDM2 rs2279744) were genotyped in 119 women suffering PE and 99 without preeclampsia. The genotyping was performed by allelic discrimination using a Taqman SNP genotype analyzer. Considering clinical features, the mean of birth weight was lower among children delivered by PE women (p=0.004). Also, a higher number of children from PE women was classified as having Low Birth Weight (p<0.001). PE women had Cesarian delivery more frequently than controls (p=0.. View More»
  DOI: 10.4172/2375-4508.1000135

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