Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
José de la Fuente
Instituto de Investigación en Recursos, Cinegéticos IREC-CSIC-UCLM-JCCM,
Ronda de Toledo s/n, 13005 Ciudad Real
Spain
Research Article
Transcriptomics Data Integration Reveals Jak-STAT as a Common Pathway Affected by Pathogenic Intracellular Bacteria in Natural Reservoir Hosts
Author(s): Ruth C. Galindo and José de la FuenteRuth C. Galindo and José de la Fuente
The study of the host-pathogen interface in natural reservoir hosts is essential to identify host-cell mechanisms affected by bacterial infection and persistence. Herein we used the Database for Annotation, Visualization and Integrated Discovery (DAVID) to integrate transcriptomics data and find common host-cell biological processes, molecular functions and pathways affected by pathogenic intracellular bacteria of the genera Anaplasma, Brucella and Mycobacterium during infection and persistence in two natural reservoir hosts, wild boar and sheep. The results showed that the upregulation of host innate immune pro-inflammatory genes and signaling pathways constitutes a general antibacterial mechanism in response to intracellular bacteria. Pathway focused analysis revealed a role for the Jak-STAT pathway during bacterial intracellular infection, a fact reported before in Mycobacterium in.. View More»
DOI:
10.4172/jpb.1000221