Angiology: Open Access
Open Access

José Ramón Gonzalez

Publications

• Review Article
  Is there a Role of Intracellular Magnesium in Prevention of Heart Failure?
  Author(s): Panayotis Fantidis, Eladio Sanchez, Ijaz Khan, Ibrahim Tarhini, Tomás Pineda, José Antonio Corrales and José Ramón Gonzalez Panayotis Fantidis, Eladio Sanchez, Ijaz Khan, Ibrahim Tarhini, Tomás Pineda, José Antonio Corrales and José Ramón Gonzalez
  
  Heart failure, characterized by the reduction in left and /or right ventricular function, is the most common cause of mortality and morbidity in almost around the world. This syndrome is induced by ?1-adrenergic receptor (?1-AR) desensitization, which in turn is caused by the reduction in cellular cAMP concentration. Cellular cAMP concentration is modulated by adenylyl cyclases (ACs), a family of enzymes that are strongly activated by intracellular magnesium and circulating levels of the stress-related hormones. Short-term activation of ?1-AR signalling pathway by increased levels of these hormones induces an increase in intracellular Mg2+ and cAMP concentrations, which improves cardiac function. Nevertheless, long-term activation of ?1-AR signalling pathway by elevated levels of these hormones reduces intracellular Mg2+ and cAMP levels, which deteriorates cardiac function. Intracellular.. View More»
  DOI: 10.4172/2329-9495.1000148

  Abstract PDF

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