Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Josef Bodor
Institute of Immunology,
Langenbeck str. 1, D-55131 Mainz
Germany
Review Article
Hematopoietic Stem Cell-Based Therapy for HIV Disease: A Role for Regulatory T Cells
Author(s): Josef Bodor, Petr Kobylka and Gero HuetterJosef Bodor, Petr Kobylka and Gero Huetter
The goal of this review is to develop insight and understanding of the effect of deleting the chemokine receptor CCR5 in T cells, and its interplay with immune regulation of Human Immunodeficiency Virus type–1 (HIV-1), to enable a novel technology platform to cure HIV disease. A critical point is the use Hematopoietic Stem Cell (HSC) transplantation of the cells resistant to HIV such as CCR5Δ32 cells, which harbor deletion in the CCR5 promoter. Such mutations, which spontaneously occur in 4-15% of the European or US populations confer resistance to CCR5-tropic HIV-1 in homozygous individuals and could cure HIV-1 disease based on the outcome of bone marrow engraftment in HIV+ leukemic patients using a CCR5Δ32 homozygous donor (e.g. ‘Berlin Patient’). However, potential shift of HIV tropism to CXCR-4 tropic strains of HIV-1 is limiting after HSC tr.. View More»
DOI:
10.4172/2155-9899.1000300