Clinical & Experimental Cardiology
Open Access

Joseph Horn

Publications

• Research Article
  The Appraisal-Trial: Evaluating RESTEN-MP^TM in Patients with Bare Metal Stent De Novo Native Coronary Artery Lesions
  Author(s): Sebastian Philipp, Stefan Sack, Igor Kordish, Johannes Brachmann, Stefan Hardt, Joseph Horn, Raimund Erbel and Dirk Böse Sebastian Philipp, Stefan Sack, Igor Kordish, Johannes Brachmann, Stefan Hardt, Joseph Horn, Raimund Erbel and Dirk Böse
  
  Neointimal hyperplasia is one of the key components of the restenotic process. The aim of this study was to evaluate the efficacy and safety of a microbubble delivery of c-myc antisense peptide in reducing restenosis after coronary stenting in de novo stenosis with intravascular ultrasound. A Multi-Link Zeta bare metal stent was implanted in de novo coronary artery lesions (RD ≥ 2.5- ≤ 4.0 mm; TL ≥ 15- ≤ 30 mm in length). Serial intravascular ultrasound analyses were performed in 25 lesions. A dose of 16mg RESTEN-MPTM (AVI BioPharma supplied by Global Therapeutics LLC) was intravenously administered after stenting and again 24 hours later. In three centres in Germany a total of 50patients (51 lesions) were enrolled, 34 in Essen, 13 in Coburg and 3 in Heidelberg. Before stenting, the minimal lumen diameter (MLD) and length of stenosis were deter.. View More»
  DOI: 10.4172/2155-9880.1000218

  Abstract PDF

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