Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Julio Dueñas-Chacón

Publications

• Research Article
  High Levels of DNA Fragmentation Observed in an Infertile Population Attending a Fertility Center are Related to Advanced Paternal Age
  
  Author(s): Javier García-Ferreyra, Rocio Romero, Roly Hilario and Julio Dueñas-ChacónJavier García-Ferreyra, Rocio Romero, Roly Hilario and Julio Dueñas-Chacón
  
  Purpose: To evaluate the effects of male aging on semen quality and DNA fragmentation in male infertility patients attending Andrology Laboratory at fertility center. Methods: Semen samples of 217 infertile patients were analyzed using Computer-Assisted Semen Analysis (CASA). Sperm DNA fragmentation was measured by the sperm chromatin dispersion test. Results: Subject’s ages ranged from 21 to 68 years. The mean age was 38.45 years. The patients were distributed into four groups: <30 years, 30-39 years, 40-49 years and ≥ 50 years. Parameters of volume, pH and concentration were similar in four evaluated groups (P: NS). An age-dependent increase in sperm DNA fragmentation was observed in four evaluated groups. The patients ≥ 40 years old had spermatozoa with fragmented DNA significantly higher compared to those patients from <30 years old and 30-39 years .. View More»
  

  Abstract

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