Virology & Mycology
Open Access
ISSN: 2161-0517
ISSN: 2161-0517
Jun Li
China
Research Article
In vitro Broad Antiviral Function against HBV, HSV, H3N2 Replication by
Baicalin and Oroxylin A-7-O-Β-D-Glucoside
Author(s): Duopeng An, Jun Li, Zhongbin Guan, Xiang Wang, Shui Yu, Yunxin Zhu, Hai Huang, Xiaoyuan Yang and Jiyang Li
Duopeng An, Jun Li, Zhongbin Guan, Xiang Wang, Shui Yu, Yunxin Zhu, Hai Huang, Xiaoyuan Yang and Jiyang Li
Flavonoids have been previously shown to possess anti-viral activities In vitro. Oroxylin A-7-O-β-D-glucoside (OAG), a flavonoids produced by microbial conversion, and its substrate baicalin, were assayed for antiviral function against hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2) and influenza A virus (H3N2). Incubation with 100 μg/ml OAG or baicalin for 9 days reduced human HBV-transfected liver cell line HepG2 2.2.15 secretion of Hepatitis B surface antigen (HBsAg) by 83.17%, and 47.175%, respectively, and Hepatitis B e antigen (HBeAg) by 27.35%, 25.56% respectively.
OAG and baicalin inhibited HSV-II-induced cell death in a concentration dependent manner (ranging from by 75% and 62.5%, respectively at 12.5 μg/ml and 50%, 37.5%, respectively at 6.25 μg/ml).
OAG (100 μg/ml) and biacalin (50 μg/ml) also effectively inhibited H3N2-.. View More»
DOI:
10.4172/2161-0517.1000165