Translational Medicine
Open Access

Junhui Sun

Publications

• Review Article
  Cardioprotective Role of Caveolae in Ischemia-Reperfusion Injury
  Author(s): Junhui Sun, Tiffany Nguyen, Mark J Kohr, Sara Menazza and Elizabeth Murphy Junhui Sun, Tiffany Nguyen, Mark J Kohr, Sara Menazza and Elizabeth Murphy
  
  Caveolae are flask-like invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the marker protein caveolin and the coat protein cavin. In cardiomyocytes, multiple signaling molecules are concentrated and organized within the caveolae to mediate signaling transduction. Recent studies suggest that caveolae and caveolaeassociated signaling molecules play an important role in protecting the myocardium against ischemia-reperfusion injury. For example, cardiac-specific overexpression of caveolin-3 has been shown to lead to protection that mimics ischemic preconditioning, while the knockout of caveolin-3 abolished ischemic preconditioning. In this review, we discuss the molecular mechanisms and signaling pathways that are involved in caveolae-mediated cardioprotection, and examine the potential for caveolae as a therapeutic target for pharmaceutical intervention to trea.. View More»
  DOI: 10.4172/2161-1025.1000114

  Abstract PDF

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