Biochemistry & Pharmacology: Open Access
Open Access

Junichiro Nakagawa

Publications

• Research Article
  Matrix Metalloproteinase-9 Triggers the Gap Junction Impairment and Somatosensory Neuronal Dysfunction in Septic Encephalopathy
  Author(s): Huan Wang, Yukio Imamura, Naoya Matsumoto, Nao Yoshikawa, Junichiro Nakagawa, Kazuma Yamakawa, Tomoki Yamada, Yuki Murakami, Satoko Mitani, Takashi Jin, Hiroshi Ogura, Takeshi Shimazu and Akitoshi Seiyama Huan Wang, Yukio Imamura, Naoya Matsumoto, Nao Yoshikawa, Junichiro Nakagawa, Kazuma Yamakawa, Tomoki Yamada, Yuki Murakami, Satoko Mitani, Takashi Jin, Hiroshi Ogura, Takeshi Shimazu and Akitoshi Seiyama
  
  Although septic encephalopathy leads to be the devastating neurological symptoms including sensory dysfunction, cognitive impairment and unconsciousness, potent substrates and their effects inducing the synaptic dysfunction remain obscure. In this study, we successfully characterized the sensory dysfunction with immunohistochemistry, immunoblotting and electrophysiology. A mouse model of septic encephalopathy was examined at 20 hrs after cecal ligation and puncture or intraperitoneal injection of lipopolysaccharide (1 mg). We found several effects of active enzyme of matrix metalloproteinases-9 (active MMP-9) on the somatosensory cortex, thalamus and prefrontal cortex related to the sensory functions in septic encephalopathy. At first, active MMP-9 was up-regulated. Second, both of the occludin, tight junction protein composing blood brain barrier, and the connexin-43, transmembrane p.. View More»
  DOI: 10.4172/2167-0501.1000108

  Abstract PDF

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