Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Jun-tao Han
Indiana
Commentary
Peroxisome Proliferator-Activated Receptor Gamma (PPAR-Γ) Agonist
Troglitazone Suppresses Collagen Synthesis via Expression of the Downstream
Target Mirnas: A Novel Strategy to Treat Skin Fibrosis?
Author(s): Hua-yu Zhu, Wen-dong Bai, Hong-tao Wang, Jun-tao Han and Da-hai HuHua-yu Zhu, Wen-dong Bai, Hong-tao Wang, Jun-tao Han and Da-hai Hu
Nuclear receptor peroxisome proliferator-activated receptor-γ (PPAR-γ) activity has been identified as an important endogenous anti-fibrotic defense mechanism. Troglitazone, a PPAR-γ agonist, has been used to suppress the formation of keloids and growth of hypertrophic scar fibroblasts. Indeed, the PPAR-γ agonist was able to inhibit collagen I expression in hypertrophic scar fibroblasts, which clearly demonstrates its therapeutic potential, and clarification of the underlying molecular mechanisms could further indicate the usefulness of the PPAR-γ agonists in the treatment of keloids. Moreover, increasing evidence has suggested that aberrant expression of miRNAs leads to the development and progression of fibrosis diseases. Thus, fully understanding the biological functions and molecular mechanisms of miRNAs in the regulation of fibrosis could provide ins.. View More»
DOI:
10.4172/2167-7700.1000218