Chemotherapy: Open Access
Open Access

Kaijun Huang

Publications

• Editorial
  Targeting the PD-1 Pathway in MSI-Stable Metastatic Colorectal Cancer
  Author(s): Kaijun Huang and Jennifer WuKaijun Huang and Jennifer Wu
  
  In patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer (CRC), the inhibition of programmed death-1 (PD-1) pathway has achieved promising response [1]. PD-1 is an immune inhibitory receptor, expressed in many cells, including T cells. Its ligand, PD-L1, is expressed on surface of several cell types, especially tumor cells. When PD-L1 binds to PD-1, an inhibitory signal is transmitted into the T cell, which suppresses T-cell proliferation. MSIH metastatic CRC gives rise to high percentage of mutations which is proportional to mutational load. High mutational load of MSI-H CRC correlates with increased PD-L1 expression which indicates a higher likelihood of response to PD-1 inhibitors, compared to microsatellite instability-stable (MSI-S) CRC [2-4]. Нus, MSI-H CRC could respond to single agent PD-1 pathway inhibition... View More»
  DOI: 10.4172/2167-7700.1000e132

  Abstract PDF

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