Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Research Article
Synthesis of Pyrazolo Linked Pyridine Carboxylic Acids and Evaluation of their Liquid Crystal and Biological Studies
Author(s): Kallashettihally Rangappa Mahendra, Kuriya Madavu Lokanatha RaiKallashettihally Rangappa Mahendra, Kuriya Madavu Lokanatha Rai
The present work deals with the synthesis and characterization of the pyrazole substituted pyridine carboxylate and carboxylic acid. The synthesized compounds are key intermediates for the synthesis of Apixaban. Apixaban is an anti-thromboembolic drug and also used as an anti-coagulating agent. Iodine substituted piperidine is the precursor material, it is treated with the chloroform and lactam to give substituted pyridine. The substituted pyridine is reaction with morpholine and the morpholine substituted compound is treated with an hydrazono acetate to give the piperidine carboxylate and limited hydrolysis to give pyridine carboxylic acids. The intermediate carboxylates and carboxylic acids are characterized for their biological and liquid crystal studies. The synthesized compounds have not showing any biological activity towards antibacterial and anti fungal assay. Further the fina.. View More»