Immunome Research
Open Access
ISSN: 1745-7580
+44-20-4587-4809
ISSN: 1745-7580
+44-20-4587-4809
Kamel S
Sudan
Research Article
In silico Prediction of Peptide based Vaccine against Fowlpox Virus (FPV)
Author(s): Idris ST, Salih S, Basheir M, Elhadi A, Kamel S, Abd-elrahman KA, Hamdi A and Hassan MAIdris ST, Salih S, Basheir M, Elhadi A, Kamel S, Abd-elrahman KA, Hamdi A and Hassan MA
Fowlpox virus (FPV) is double stranded DNA virus and a member of Poxviridae family which transmitted via aerosols and insect bite and causes cutaneous and diphtheritic infection in poultry population. This study aimed to design peptide vaccine by selecting all possible epitopes after analyzing of all FPV140 protein sequence reported in NCBI database using in silico approaches. After alignment of retrieved sequence the conserved region applied into IEDB analysis tool to predict B and T cell epitopes, then testing the affinity of predicted epitopes to bind to (BF2*2101) (BF2*0401) chicken receptor for MHC1 molecule, peptides low energy when docked against receptor were suggested as epitopes based vaccine. Peptides (50 PPSPKP 55, 51 PSPKPL 56, 52 SPKPLP 57, 53 PKPLPK 58, 54 KPLPKS 59, 55 PLPKSK 60, 56 LPKSKQ 61 and 18 RPSSTV 23) were most potential B cell epito.. View More»
DOI:
10.4172/1745-7580.1000154