Journal of Clinical Toxicology
Open Access

Kareli Dimitra

Publications

• Research Article
  Amifostine Protects the White Cell Line Against Genotoxic Damage in Patients Undergoing Pelvic Radiotherapy
  Author(s): Pouliliou Stamatia, Papaiakovou Marina, Kareli Dimitra, Lialiaris Theodore and Koukourakis I MichaelPouliliou Stamatia, Papaiakovou Marina, Kareli Dimitra, Lialiaris Theodore and Koukourakis I Michael
  
  X-rays are widely used in the treatment of cancer. Nevertheless, radiation may induce damage to normal tissues, through free radical release and Deoxyribonucleic acid (DNA) damage. Amifostine is a broad spectrum cytoprotective agent with free radical scavenger and DNA repair activity that reduces toxicity during radiotherapy and chemotherapy. The aim of the present in vivo study was to investigate the cytoprotective efficacy of amifostine against chromosomal damage induced on peripheral blood lymphocytes in cancer patients under radiotherapy for pelvic tumors. The levels of genotoxicity, cytostaticity and cytotoxicity were quantitatively evaluated using the Sister Chromatid Exchange (SCE) methodology, the Proliferation Rate Index (PRI), the Mitotic Index (MI). PBMCs were collected at 0, 5 and 19 days from patients with pelvic tumors undergoing daily fractionated radiotherapy. Five pat.. View More»
  DOI: 10.4172/2161-0495.1000139

  Abstract PDF

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