Journal of Clinical Trials
Open Access

Karen EA Burns

Publications

• Protocol
  Parallel Pilot Trials of Screening Frequency for Liberation from Mechanical Ventilation the RELEASE Trial and SENIOR Trial Protocols
  Author(s): Karen EA Burns, Jessica TY Wong, Leena Rizvi, Lori Hand, Deborah J Cook, Peter Dodek, Sangeeta Mehta, Michelle E Kho PT, Francois Lamontagne, Jan O. Friedrich, Andrew J Seely, Laurent Brochard, Eddy Fan, Christine Leger, Fatma Rajwani, Julia Lee RRT, Kevin Thorpe and Maureen O Meade Karen EA Burns, Jessica TY Wong, Leena Rizvi, Lori Hand, Deborah J Cook, Peter Dodek, Sangeeta Mehta, Michelle E Kho PT, Francois Lamontagne, Jan O. Friedrich, Andrew J Seely, Laurent Brochard, Eddy Fan, Christine Leger, Fatma Rajwani, Julia Lee RRT, Kevin Thorpe and Maureen O Meade
  
  Rationale: Reducing the duration of invasive ventilation is a priority in the intensive care unit (ICU). Once daily screening to identify candidates for spontaneous breathing trials (SBTs) is poorly aligned with the continuous care ICU environment. Objectives: The primary objective of the pilot randomized RELEASE and SENIOR trials is to assess our ability to recruit 50 non-elderly (<65 years) and 100 elderly (> 65 years) critically ill adults into parallel trials comparing once vs at least twice daily screening. Secondary objectives are to evaluate clinicians’ adherence to the screening protocols, assess current practices related to management of sedation, analgesia, delirium and patient mobilization before screening assessments, identify barriers to enrollment, characterize trial participants based on weaning difficulty, and obtain preliminary estimates of the alternative.. View More»
  DOI: 10.4172/2167-0870.1000236

  Abstract PDF

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