Journal of Alcoholism & Drug Dependence
Open Access

Karen Jansen

Publications

• Research Article
  Alcohol Use Disorder and Inflammatory Cytokines in a Population Sample of Young Adults
  Author(s): Alethea Zago, Fernanda Pedrotti Moreira, Karen Jansen, Alfredo Cardoso Lhullier, Ricardo Azevedo da Silva, Jacqueline Flores de Oliveira, João Ricardo Carvalho Medeiros, Gabriela Delevati Colpo, Luis Valmor Portela, Diogo R. Lara, Luciano Dias de Mattos Souza, Jean Pierre Oses and Carolina David Wiener Alethea Zago, Fernanda Pedrotti Moreira, Karen Jansen, Alfredo Cardoso Lhullier, Ricardo Azevedo da Silva, Jacqueline Flores de Oliveira, João Ricardo Carvalho Medeiros, Gabriela Delevati Colpo, Luis Valmor Portela, Diogo R. Lara, Luciano Dias de Mattos Souza, Jean Pierre Oses and Carolina David Wiener
  
  Background: Alcohol abuse is followed by neuroadaptive brain changes, in addition to inducing changes in the immune system. The objective of this study was to investigate the peripheral levels of proinflammatory (IL-6, and TNF-α) and anti-inflammatory (IL-10) cytokines, as well the inflammatory balance in relation to alcohol use in subjects from a young population-based sample. Methods: This is a cross-sectional study nested in a population-based study of people aged 18–35 years, involving 629 participants. The CAGE questionnaire was used to evaluate Alcohol Use Disorder, and CAGE scores ≥ 2 were considered a positive screen for alcohol use disorder. Serum levels of IL-6, IL-10 and TNF-α were measured by ELISA using a commercial kit. Results: T.. View More»
  DOI: 10.4172/2329-6488.1000236

  Abstract PDF

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