Journal of Proteomics & Bioinformatics
Open Access

Karina Kleinfelder-Fontanesi

Publications

• Research Article
  Metabolic and Inflammatory Proteins Differentially Expressed in Platelets from Unprovoked Deep Vein Thrombosis Patients
  Author(s): Mariane C Flores-Nascimento, Karina Kleinfelder-Fontanesi, Thiago Matos de Araujo, Gabriel Forato Anhe, Rodrigo Secolin, Fernanda Andrade Orsi, Erich Vinicius de Paula and Joyce M Annichino-Bizzacchi Mariane C Flores-Nascimento, Karina Kleinfelder-Fontanesi, Thiago Matos de Araujo, Gabriel Forato Anhe, Rodrigo Secolin, Fernanda Andrade Orsi, Erich Vinicius de Paula and Joyce M Annichino-Bizzacchi
  
  Deep vein thrombosis (DVT) is multi-causal disease associated to high morbidity and mortality due to complications, especially from pulmonary embolism. New factors of relevance on the DVT pathophysiology enhance our understanding of disease mechanisms and can be translated into improved management of patients, prevention of recurrence and development of new therapies. In this context, the precise role of platelets in the pathogenesis of DVT is not completely understood. Our objectives were to acquire and to analyze the whole platelet protein profile of samples from 3 DVT patients and to compare them to results obtained from 1 sibling and 1 neighbor from each patient (in order to minimize genetic and environmental interferences). These patients presented unprovoked and recurrent episodes of proximal DVT as well as a family history of DVT. Platelets were washed, lysed, and the proteins .. View More»
  DOI: 10.4172/jpb.1000298

  Abstract PDF

Relevant Topics