Journal of Applied Pharmacy
Open Access

Karthikeyan Muthusamy

Publications

• Research Article
  Nanopeptides: Non - Covalent Interactions in Chemistry and Biological Functions
  Author(s): Chinnasamy Selvakkumar, Karthikeyan Muthusamy and Sathish Kumar Chinnasamy Chinnasamy Selvakkumar, Karthikeyan Muthusamy and Sathish Kumar Chinnasamy
  
  The interactions involving the side chains of weakly polar aromatic amino acid residues, e.g., Phenylalanine (Phe), Tyrosine (Tyr) and Tryptophan (Trp) generally reside at the interior of proteins and help in the stabilization of globular protein structures. The aromatic electron cloud of the aromatic rings of these amino acids are delocalized on both sides of the planer rings, so that there is a small partial negative charge on the face and a small partial positive charge on the hydrogen atoms of the edge, which leads to the possibility of electrostatic interactions. These interaction play a vital role nanofiber based vaccine adjuvants, and cocaine vaccine development and increasing interest and structure-based drug development. Apart from electrostatic forces, aromatic interactions also consist of van der Waals and hydrophobic forces. These weakly polar interactions are enthalpicall.. View More»
  DOI: 10.4172/1920-4159.1000218

  Abstract PDF

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