Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Kathryn Kennedy
Tulane Cancer Center,
New Orleans, LA
Tanzania
Review
Molecular Chemotherapies in Gynecologic
Author(s): Kathryn Kennedy* and William Robinson
Kathryn Kennedy* and William Robinson
The development of chemotherapy agents that precisely target specific molecular structures in cancer cells has become a priority in oncology research. In principal, this method halts cancer cell proliferation while allowing normal function of healthy cells. These molecular-based chemotherapy agents target many types of molecules involved in the growth, spread, and survival of malignant cells. Several of these target molecules have been identified in female genital tract malignancies, and multiple agents targeted at those molecules have been developed as treatment.
This review outlines three major types of targeted agents that have clinical relevance in the treatment of gynecologic cancer. The first group of drugs inhibits vascular endothelial growth factor (VEGF), which normally facilitates angiogenesis. The second group inhibits poly ADP ribose polymerase, a base-excision enzy.. View More»
DOI:
10.4172/2167-7700.1000242