Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Kay B Leissner
Tanzania
Research Article
The Progression of Isoflurane-induced Malignant Hyperthermia and Its Attenuation by Cisatracurium in a Pre-clinical Porcine Model of Heart Transplant
Author(s): Samar K Lowalekar, Haiyan Cao, Xiu-Gui Lu, Patrick R Treanor, Charles K Allam, Vladimir Birjiniuk, Kay B Leissner and Hemant S ThatteSamar K Lowalekar, Haiyan Cao, Xiu-Gui Lu, Patrick R Treanor, Charles K Allam, Vladimir Birjiniuk, Kay B Leissner and Hemant S Thatte
Background: Even after several years of study, the intra-operative diagnosis of Malignant Hyperthermia (MH) and the approach to anesthesia in MH-susceptible individuals has remained a challenge. In this study we present the pre-operative and intra-operative findings of development and progression of MH in a porcine model that was assigned for heart transplants.
Methods: Female Yorkshire swine were assigned as either donor or recipient and anesthetized with inhalational isoflurane with or without cisatracurium. The inadvertent development of signs indicating MH, including, alterations required in ventilator/bypass machine settings, arterial and venous blood tests, gross- and histo-pathology, were followed through the surgeries that lasted for variable durations between donors and recipients.
Results: Both donors and the.. View More»
DOI:
10.4172/2155-6148.1000365