Journal of Clinical and Cellular Immunology
Open Access

Keiko Furukawa

Publications

• Short Communication
  Inflammatory Reactions in Microenvironments, Leading to Melanomagenesis
  Author(s): Koichi Furukawa, Maiko Miyata, Mariko Kambe, Rika Takeuchi, Robiul H. Bhuiyan, Pu Zhang, Yuhsuke Ohmi and Keiko Furukawa Koichi Furukawa, Maiko Miyata, Mariko Kambe, Rika Takeuchi, Robiul H. Bhuiyan, Pu Zhang, Yuhsuke Ohmi and Keiko Furukawa
  
  Malignant melanoma is resistant to various therapies, while its incidence has been dramatically increasing. Among various factors, sun exposure, particularly ultra violet (UV) irradiation is considered to induce melanomas. Gangliosides have been markers of neuro-ectoderm-derived cancers like malignant melanomas and gliomas, but they also play crucial roles in their malignant properties. GD3 regulates cell signalling transduced through membrane microdomains. Chronic inflammatory reactions toward noxious stimuli cause cumbersome diseases such as cancers and degeneration, and glycosylation is involved in those processes. Here, melanocytes did not respond to UVB, while keratinocytes responded to UVB by secreting various cytokines such as TNFα and IL-6. Furthermore, these cytokines induced expression of melanoma-associated ganglioside GD3 on melanocytes. Expression of GD3 does not ne.. View More»
  DOI: 10.4172/2155-9899.1000508

  Abstract PDF

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