Clinical & Experimental Cardiology
Open Access

Keizo Ohbu

Publications

• Research Article
  Circulating Myeloid Dendritic Cells is Decreased in the Acute Phase of Kawasaki Disease
  Author(s): Kenji Suda, Shintaro Kishimoto, Tomoyuki Takahashi, Hiroshi Nishino, Hisayoshi Okamura, Yozo Teramachi, Takato Yokoyama,Hideo Yasukawa, Keizo Ohbu, Tsutomu Imaizumi and Toyojiro Matsuishi Kenji Suda, Shintaro Kishimoto, Tomoyuki Takahashi, Hiroshi Nishino, Hisayoshi Okamura, Yozo Teramachi, Takato Yokoyama,Hideo Yasukawa, Keizo Ohbu, Tsutomu Imaizumi and Toyojiro Matsuishi
  
  Background: Kawasaki disease is the most prevalent vasculitis of children in the developed countries that affects middle-sized arteries. Though T-cells are known to be activated with ample production of cytokines in acute phase of Kawasaki disease, there is a paucity of data concerning dendritic cells (DCs), the most potent antigen presenting cells that initiates T-cell activation. This study examined change in circulating DCs in acute phase of Kawasaki disease. Methods: Using multi-color flow cytometry, we determined circulating myeloid DC (mDC), Lin-HLA-DR+CD11c+ cell, and plasmacytoid DC (pDC), Lin-HLA-DR+CD123+ cell in 33 patients with acute phase of Kawasaki disease (aKD), 24 febrile controls (FC), and 13 healthy controls (HC). Blood chemistry data including cytokines were determined at the same time. Numbers of DCs were compared among .. View More»
  

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