Pediatrics & Therapeutics
Open Access

Kenji Hoshino

Publications

• Research Article
  Electrolyte Imbalance Caused by Diuretic Therapy in Infants with Congenital Heart Diseases
  Author(s): Kiyoshi Ogawa, Fumie Kawachi, Takuma Mori and Kenji Hoshino Kiyoshi Ogawa, Fumie Kawachi, Takuma Mori and Kenji Hoshino
  
  Background: Although furosemide and spironolactone are widely used to treat heart failure in infants and children because of their effectiveness and few side effects, there have been no prospective studies about the frequency and degree of serum electrolyte abnormality after the use of diuretics in pediatric patients. Methods: We prospectively studied 126 infants at our outpatient clinic aged less than 2 months old with left-toright shunt who received oral diuretics. All patients were started on furosemide at 0.5~3 mg/kg/day and spironolactone at 0.5~2 mg/kg/day, orally divided into two or three doses according to the degree of congestive heart failure. Results: Serum sodium level ranged from 128 to 142 mEq/L (mean 136 mEq/L) and was <134 mEq/L in 18 of 126 patients (14.3%). Serum potassium level ranged from 4.5.. View More»
  DOI: 10.4172/2161-0665.1000313

  Abstract PDF

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