Andrology-Open Access
Open Access

Kevin T McVary

Publications

• Research Article
  Nitric Oxide Synthase is Necessary for Normal Urogenital Development
  Author(s): Christopher Bond, Omer Onur Cakir, Kevin T McVary and Carol A Podlasek Christopher Bond, Omer Onur Cakir, Kevin T McVary and Carol A Podlasek
  
  Introduction: Neuronal nitric oxide synthase (NOS-I) is significantly decreased with Cavernous Nerve (CN) injury in Erectile Dysfunction (ED) models. Increased apoptosis and collagen deposition accompany decreased NOS/CN injury, however these changes are typically attributed to the altered signaling of other factors, and a contribution of NOS in maintenance of urogenital structures has not previously been examined. Morphological changes in the corpora cavernosa occur at the same time as decreased NOS, suggesting a potential connection between decreased/inhibited NOS and morphological changes associated with ED. In this study we propose that NOS impacts urogenital morphology during development and will examine this hypothesis by NOS inhibition with L-NAME. Methods: Primary outcomes were H&E, western and TUNEL to determine if penis, prostate and bladder morphology were alt.. View More»
  DOI: 10.4172/2167-0250.1000108

  Abstract PDF

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