Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Khansari Nematollah
Iran, Islamic Republic of
Research Article
Measurement of Serum Levels of Interleukin 17 and 23 in the Immune System with Different Amounts of Spleens White Pulp Size after Inoculation of New Leishmania Vaccine in Susceptible Mice
Author(s): Afshineh Latifynia*, Mohammad Javad Gharagozlou, Reza Agha Ebrahimi Samani, Soror Charedar, Bagheri Hadi, Hajjaran Homa and Khansari Nematollah
Afshineh Latifynia*, Mohammad Javad Gharagozlou, Reza Agha Ebrahimi Samani, Soror Charedar, Bagheri Hadi, Hajjaran Homa and Khansari Nematollah
Objective: Different species of Leishmania parasite can cause leishmaniasis and its prevalence is growing in Iran and same as in other parts of the world is twice every ten years. According to studies conducted an effective vaccine is better way to prevent this disease than anthers.
Method: In our study, six groups were vaccinated and the seventh group was control group. The vaccine groups received two injection doses (100 and 200 micrograms/0.1 ml) of cocktail leishmania vaccine respectively both with two adjuvants ( Teucrium Polium or BCG).
Results: Results showed that mice survived along study period in all vaccinated groups. The serum cytokine’s results showed that IL-23 was highest in group LT100 μg/0.1 ml and group LBT 200 μg/0.1 ml was lowest, and, highest IL-17 related to control and.. View More»
DOI:
10.4172/2155-9899.1000527