Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Research Article
Immunoinformatics-Peptide Driven Vaccine and In silico Modeling for Duvenhage Rabies Virus Glycoprotein G
Author(s): Sahar Obi Abd Albagi, Omar Hashim Ahmed, Manal Abdalla Gumaa, Khoubieb Ali Abd_elrahman, Ahmed Hamdi Abu-Haraz and Mohammed A. Hassan
Sahar Obi Abd Albagi, Omar Hashim Ahmed, Manal Abdalla Gumaa, Khoubieb Ali Abd_elrahman, Ahmed Hamdi Abu-Haraz and Mohammed A. Hassan
Background: Duvenahge rabies virus belongs to Lyssavirus genus family Rhabdoviridae causing fatal infection with no effective treatment available and no licensed DNA or peptide vaccine up to date. The aim of present study was to predict peptide vaccine for Duvenhage rabies virus.
Methods and materials: The sequences of Duvenahge virus was optioned from NCBI, and then it was subjected to many B cell and T cell tests from IEDB to realize the most promising peptides that could act as driven-peptide vaccine. Population coverage analysis was performed for selected peptides using IEDB and finally homology modeling and molecular docking studies were done to visualize the interaction with MHC1 molecules.
Result and conclusion: Among the tested peptides for T cell-test, this study projected an interesting epitope of T cell (YFLIG.. View More»
DOI:
10.4172/2155-9899.1000517