Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Kiho Araki
Japan
Review Article
Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimer’s Disease
Author(s): Tomone Nagae, Kiho Araki, Yuki Shimoda, Lucia I. Sue, Thomas G. Beach and Yoshihiro Konishi
Tomone Nagae, Kiho Araki, Yuki Shimoda, Lucia I. Sue, Thomas G. Beach and Yoshihiro Konishi
Inflammatory mechanisms are implicated in the pathology of Alzheimer’s disease (AD). However, it is unclear whether inflammatory alterations are a cause or consequence of neurodegeneration leading to dementia. Clarifying this issue would provide valuable insight into the early diagnosis and therapeutic management of AD. To address this, we compared the mRNA expression profiles of cytokines in the brains of AD patients with “non-demented individuals with AD pathology” and non-demented healthy control (ND) individuals. “Non-demented individuals with AD pathology” are referred to as high pathology control (HPC) individuals that are considered an intermediate subset between AD and ND. HPC represents a transition between normal aging and early stage of AD, and therefore, is useful for determining whether neuroinflammation is a cause or consequence of AD pathol.. View More»
DOI:
10.4172/2155-9899.1000441