Journal of Hematology & Thromboembolic Diseases
Open Access

King H Lam

Publications

• Research Article
  The Erythrocyte Count on Top of Bone Marrow Histology Discriminates Essential Thrombocythemia and Polycythemia Vera in JAK2v617f Mutated Prefibrotic Myeloproliferative Neoplasm with No or Minor Splenomegaly
  Author(s): Jan Jacques Michiels, Wilfried Schroyens, Jan Lindemans, Fibo WJ Ten Kate, King H Lam and Hendrik De RaeveJan Jacques Michiels, Wilfried Schroyens, Jan Lindemans, Fibo WJ Ten Kate, King H Lam and Hendrik De Raeve
  
  Blood and bone features in JAK2V617F mutated prefibrotic essential thrombocythemia (ET) and polycythemia vera (PV) are overlapping in terms of increased cellularity due to increased erythropoiesis and pleomorphic megakaryocytes indicating the need to measure red cell mass (RCM) according to PVSG and WHO criteria. The JAK2V617F mutated myeloproliferative neoplasms (MPN) appeared to be a broad biological continuum of normocellular ET, ET with features of polycythemia vera (prodromal PV), classical PV, advanced PV, Inapparent PV (IPV) with splenomegly, masked PV or hypercellular ET due to megakaryocytic granulocytic myeloproliferation (ET.MGM) when the 2013 WHO and European Clinical, Molecular and Pathological (WHO-CMP) criteria are applied. The megakaryocytes morphology may change from pleomorphic to dysmorphic in advanced PV, in IPV and in masked PV (ET.MGM) as bone marrow cellularity,.. View More»
  DOI: 10.4172/2329-8790.1000153

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